Zeng-Qiang Yuan

Magnetic Nanoparticle‐Mediated PTEN Inhibition Promotes Directional Neurite Growth for Spinal Cord Injury Repair

Adult mammalian spinal cords have limited regenerative capacity, and spinal cord injury (SCI) often causes permanent neurological deficits. Although genetic interventions may enhance intrinsic growth capacity in injured neurons, axonal extension after SCI may remain spatially limited and poorly organized, which may r...

Functional Dissociation of Anterior Cingulate Cortex Excitatory and Inhibitory Neurons in Sustained Attention and Impulse Control.

Activation of sigma non-opioid intracellular receptor 1 (S1R) receptor inhibits plexin domain containing 2 (Plxdc2) driven microglial inflammation to ameliorate depressive-like behaviours in mice.

Analysis demonstrated that overexpressing Plxdc2 in mPFC microglia activated the JAK2-STAT1 pathway, enhanced NLG, shifting microglia towards a pro-inflammatory phenotype, worsening deficits in synaptic plasticity and induced depressive-like behaviour, which was reversible by the NLG inhibitor tunicamycin.

Neuroinflammation and neurodegeneration: Linking mechanisms, biomarkers, and therapeutic opportunity

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