Lateral flow assays (LFAs) are widely used in point-of-care diagnostics due to their rapid readout, low cost, and operational simplicity; however, their limited sensitivity hinders the detection of low-abundance biomarkers. Existing signal amplification strategies often fail to precisely modulate signal intensity while...
Bao-Hong He, Xi-Wei Wang, Xiao-Lu Han et al.· Biosensors & bioelectronics· 0 citations
mRNA vaccines have become a clinically validated vaccine platform, as demonstrated by the success of COVID-19 vaccines such as Comirnaty and Spikevax, owing to their rapid design, manufacturing scalability, and capacity to induce in situ antigen expression. A key factor underlying this success is the lipid nanoparticle...
Zhi-Neng Wu, Jinghu Lou, Yi Cheng et al.· Molecular Biomedicine· 0 citations
Botulinum neurotoxins (BoNTs) are the most potent biological toxins discovered to date. Rapid capture and clearance of BoNTs from the bloodstream is a critical strategy for poisoning treatment. Nanobodies, with their high affinity, represent promising molecules for neutralizing BoNTs. Due to its small molecular weight,...
Youqing Chu, Xiwei Wang, Yabing Hua et al.· ACS Applied Bio Materials· 0 citations
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