Author

Zeng-Jun Lu

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Open access Oct 2026

Structural basis of antigenic drift in FMDV O/Cathay topotype variants revealed by porcine-derived single B-cell neutralizing antibodies

The porcinophilic O/Cathay topotype variants of foot-and-mouth disease virus (FMDV) continuously accumulated mutations over time and produced antigenic drift, leading to diminished serum neutralization and compromised vaccine efficacy. However, the structural basis underlying this divergence remains poorly defined. Her...

Feng-Juan Li, Shan-Quan Wu, Shu-Lun Huang et al. · PLoS Pathogens · 0 citations

Open access Sep 2026

Generation and characterization of a PRRSV-2 DIVA marker virus by deletion of a novel epitope in the nucleocapsid protein

The feasibility of developing a PRRSV DIVA vaccine through targeted modification of an N protein epitope is demonstrated, providing a potential strategy to facilitate PRRS control and suggests that combining the recombinant virus with cELISA diagnostic tests allows accurate differentiation between vaccinated and wild-t...

Ji-Wen Sun, Jian Wang, Kun Li et al. · Journal of Virology · 0 citations

Open access Aug 2026

Genome-wide CRISPR screen identifies RNF24 as a critical host factor for foot-and-mouth disease virus entry

An unbiased genome-wide CRISPR/Cas9 knockout screening using porcine cells reveals a ubiquitin-dependent RNF24-LPXN regulatory axis that supports FMDV entry, highlights the role of non-degradative ubiquitination in viral pathogenesis, and proposes this interface as a potential target for antiviral intervention.

Jin-Yan Zhang, Hai-Long Liu, Jian Du et al. · Frontiers in Cell and Develo... · 0 citations