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Author

Zemer Gitai

2 papers indexed here

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Open access Sep 2026

Release of the Staphylococcus aureus autoinducing peptide is enabled by active export of the biosynthetic intermediate

Staphylococcus aureus is a species of Gram-positive bacteria that uses the accessory gene regulator (agr) quorum sensing system to regulate many aspects of cell behavior such as virulence and toxin production. Quorum sensing is activated in dense S. aureus populations by the extracellular accumulation of a signaling mo...

Alan Tong, Kelsey M. Hallinen, Arya Bhakare et al. · 0 citations
Open access Jun 2026

Machine Learning-Guided Discovery of Bacterial-Selective Membrane-Active Compounds Reveals Mechanistic Bias in Antibiotic Training Datasets

The rise of antibiotic resistance necessitates the discovery of antibacterial compounds with novel mechanisms of action (MoAs). Recent machine learning approaches have shown promise in antibacterial compound discovery, but often identify derivatives of known antibiotic classes rather than mechanistically novel compound...

Connor Chain, Soodabeh Ghaffari, Syrine Belakaria et al. · 0 citations

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