Author

Ze-Yu Sun

2 papers indexed here

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Sep 2026

Microglial P2Y12 Drives Chronic Cerebral Hypoperfusion via Ca2+ Activity-Mediated Neuroinflammation and Vascular Injury.

BACKGROUND Chronic cerebral hypoperfusion is a major driver of vascular cognitive impairment (VCI), but the role of microglial purinergic signaling in chronic cerebral hypoperfusion-induced neurovascular dysfunction remains undefined. This hypothesis-testing study with a novel research premise aimed to address this kno...

Qian-Qian Chen, Shi-Hao Yuan, Ya-Na Wang et al. · Stroke · 0 citations

Sep 2026

SIK3-mKO Enhances Myelin Debris Phagocytosis via CD11c Complement Pathway for White Matter Protection Poststroke.

BACKGROUND White matter preservation is a rate-limiting factor in neurological recovery after ischemic stroke and depends on efficient clearance of myelin debris by microglia/macrophages. Our prior work demonstrated that microglia/macrophage-specific SIK3 (salt-inducible kinase) knockout (SIK3-mKO) promotes an anti-inf...

Lei-Lei Mao, Chen-Ran Wang, Ke Wang et al. · Stroke · 0 citations