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Ze-Lei Yang

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Sep 2026

Shikonin suppresses fibrotic phenotype and oxidative stress in keloid fibroblasts via EGFR-targeted AKT/STAT3/PTGS2 modulation.

Keloids are fibroproliferative disorders with excessive extracellular matrix (ECM) deposition, fibroblast hyperproliferation, oxidative stress, and a lack of effective therapies. Shikonin, a natural naphthoquinone, exhibits anti-tumor and antioxidant activities, yet its role in keloid fibroblasts (KFs) remains unclear....

Ze-Lei Yang, Ming-Xiang Wang, Cheng-Sheng Li et al. · 0 citations

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