Author

Zejun Fang

2 papers indexed here

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Open access Sep 2026

PIAS2 Overexpression Attenuates Erastin-Induced Ferroptotic Changes and Is Associated With Increased GPX4 Protein and Enhanced GPX4-Related SUMO3 Signaling in Hepatocellular Carcinoma Cells.

Mechanistic studies revealed that PIAS2 and GPX4 co-immunoprecipitate in HCC cells, and PIAS2 overexpression was associated with increased SUMO3 modification signals and higher remaining GPX4 protein levels at the examined 12- and 24-h CHX time points.

Xian-Guo Cai, Jiang-Wei Ye, L. Fang et al. · Frontiers in Bioscience · 0 citations

Open access Jul 2026

Lachnospiraceae and Its Metabolite Malate Act in Concert to Repair Gut Microbiota Imbalance and Block Colorectal Cancer Progression.

Lachnospiraceae bacterium biologics abstracts accession-2278 (BAA-2278) is associated with anti-CRC effects in preclinical models, potentially mediated through regulation of gut microbiota homeostasis and inhibition of Wnt/β-catenin signaling via its metabolite malate.

Ze-Jun Fang, Yan-Yan Hu, Min-Jing Zhu et al. · Frontiers in Bioscience · 0 citations