This review proposes a pathology-informed design framework that links wound-specific therapeutic needs to nanozyme screening, function optimization, and iterative refinement, and synthesizes current progress in AI-enabled material discovery and structure–activity prediction, function-oriented and multiobjective optimiz...
Duo-Cui Yang, Ze-Hang Zheng, Han Wang et al.· Bioactive Materials· 0 citations
mTORC2, defined by its core component RICTOR, is a key regulator of immune cell function and inflammation, yet its roles have long been underappreciated due to lack of specific inhibitors and in vivo tools. This review summarizes the current understanding of mTORC2-specific signaling (via AKT, SGK1, and PKC) in regulat...