Curcumin in pancreatic cancer: A comprehensive review of anticancer mechanisms, EMT modulation, and clinical challenges.
BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive local invasion, early metastasis, and profound chemoresistance. Epithelial-mesenchymal transition (EMT) is a critical driver of these aggressive phenotypes, promoting tumor cell dissemination and...