Author

Zackary Dietz

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Sep 2026

Multifunctional antibody responses from a primate Shigella outbreak inform vaccine design.

There is currently no approved vaccine for Shigella spp., a leading cause of diarrhea with increasing rates of antimicrobial resistance. Shigella vaccine development is complicated in part by an incomplete understanding of the structural and molecular determinants of immunity. To address this, we isolated monoclonal an...

Robert M. Gallant, Paul Savarino, Sophia Pulido et al. · Science Translational Medici... · 0 citations

#protein folding Open access Sep 2026

An intranasal bivalent vaccine induces antigen-specific humoral and Th1/Th17 cellular immunity and protects young and aged mice against MRSA and Pseudomonas aeruginosa skin and soft tissue infections

ABSTRACT Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are ESKAPE pathogens that are responsible for severe skin and soft tissue infections (SSTIs), particularly in the elderly and those with immunocompromising conditions. Rising rates of methicillin-resistant S. aureus (MRSA) and carbapenem-resistant PA h...

Suhrid Maiti, T. Lu, Zackary Dietz et al. · Infection and Immunity · 0 citations

Open access Aug 2026

A multivalent subunit vaccine augments pre-existing immunity to protect against T3SS-positive Pseudomonas aeruginosa but reveals immunological interference against ExlA-positive strains

It is established that the vaccine formulation can effectively boost and redirect pre-existing immunity, offering a promising approach to overcome the limitations of natural exposure and protect at-risk individuals from diverse Pa infections.

D. R. Howlader, Sayan Das, Satabdi Biswas et al. · Infection and Immunity · 0 citations