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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zachary D. Crees

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Open access Sep 2026

Mosaic TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy

Patel et al. describe an elderly woman with severe chronic neutropenia caused by mosaic TLR8 gain-of-function. The report broadens a primarily pediatric, male disease spectrum and highlights somatic mosaicism as an important diagnostic consideration in adults with unexplained cytopenia and immune dysregulation.

J. Patel, Nermina Saucier, Hwi M. Gil et al. · 0 citations
Open access Sep 2026

Making space for cures: Conditioning for autologous hematopoietic stem cell gene therapies.

Although allogeneic hematopoietic stem cell transplantation has long been the only curative therapy for nonmalignant blood diseases, recent clinical successes have demonstrated the transformative potential of autologous gene therapies as definitive treatments for these disorders. By providing durable life-changing clin...

Zachary D. Crees, J. Dipersio, Stephen P. Persaud · 0 citations

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