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Review Open access Jun 2026

Decoding Intratumoral Heterogeneity in Breast Cancer: The Evolution From Radiomics to Topological Quantification for Predicting Lymphovascular Invasion

Lymphovascular invasion (LVI) is a critical independent prognostic factor in invasive breast cancer and is strongly associated with early recurrence and distant metastasis. Accurate preoperative assessment of LVI is therefore essential for treatment planning. However, conventional needle biopsy is limited by spatial sa...

Z. Zuo, Yun-Hua Li, Ying Zeng · 0 citations
Review Aug 2026

Noninvasive Characterization of Tumor Heterogeneity in Locally Advanced Nasopharyngeal Carcinoma: From Progression-Free Survival Prediction to Biological Correlates.

BACKGROUND Locally advanced nasopharyngeal carcinoma (LA-NPC) shows substantial variability in progression-free survival (PFS) despite radiotherapy-based treatment. Clinical factors and conventional radiomics may not adequately characterize the spatial organization of intratumoral heterogeneity. Whether topology-aware...

Wei Li, Ming Yi, Guo Chen et al. · 0 citations

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