Author

Zhu Zhang

3 papers indexed here

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Open access Nov 2026

Targeting ALDOA Lactylation Reverses Vascular Remodeling in Pulmonary Hypertension by Disrupting Actin Polymerization and YAP Activation.

BACKGROUND Maladaptive vascular remodeling is a hallmark of pulmonary hypertension (PH), and therapeutic strategies directly targeting the pathological activity of smooth muscle cells remain limited. Metabolic and epigenetic dysregulation are established drivers of PH, and lysine lactylation has emerged as a novel post...

Xiao-Xu Huang, Jin-Cheng Zhang, Qing-Ye Zeng et al. · Circulation · 0 citations

Open access Oct 2026

Systemic Hypertension and Survival in Pulmonary Hypertension.

Higher baseline sSAP and preexisting systemic hypertension were independently associated with improved survival, while a higher baseline heart rate and declining systemic blood pressure during follow-up were significantly associated with increased mortality risk.

A. Yogeswaran, Max Berger, E. D. De Bie et al. · JAMA cardiology · 0 citations

Open access Aug 2026

Predictive Power of Pulmonary Artery Stiffness - Right Ventricular Interplay, but not Pulmonary Vascular Resistance, in Mild Pulmonary Hypertension: A PVRI GoDeep meta-registry analysis.

BACKGROUND Pulmonary vascular diseases are characterized by mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR), both reflecting the steady-flow component of right ventricular (RV) afterload while neglecting pulsatile elements. Pulmonary artery compliance (PAC) and arterial elastance (Ea) capt...

A. Yogeswaran, Meike Fünderich, David G. Kiely et al. · Chest · 0 citations