Imbalanced ω-6/ω-3 polyunsaturated fatty acid metabolism promotes HFpEF progression via the ANGPTL4/LPL axis-mediated lipotoxicity
Heart failure with preserved ejection fraction (HFpEF) is a growing global burden with limited therapeutic options. While lipid metabolic disorders are hallmarks of HFpEF, the specific contribution of imbalanced -6/-3 polyunsaturated fatty acids (PUFAs) to myocardial lipid handling remains poorly understood. This...