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Open access Sep 2026

Thiolactomycin-based morpholino and piperidino conjugates: synthesis, antimalarial evaluation, and PfFAS-II inhibition

Background and purpose: Malaria remains a formidable global healthcare challenge due to emerging drug-resistant Plasmodium spp., underscoring the urgent need for novel antimalarial scaffolds. Thiolactomycin, a FAS-II inhibitor, is a promising lead for structural optimization. This study aims to design, synthesize, and...

Shaik Azeeza, M. Malik, Q. M. Jamal et al. · 0 citations
Open access Oct 2026

Synthesis, characterization, biological evaluation, and computational studies of novel metal complexes derived from 1-isopropyl-1H-benzimidazole-2-carbaldehyde and tri-substituted imidazole

Two novel Ni(II) and Cu(II) mixed-ligand complexes, NiMBIM and CuMBIM, were successfully synthesized using 1-isopropyl-1H-benzimidazole-2-carbaldehyde (MB) and 2-(4,5-diphenyl-1H-imidazol-2-yl)phenol (IM). Their structures were characterized via CHN elemental analysis, UV–Vis and FT-IR spectroscopy, mass spectrometry,...

Abdulaziz M. Almohyawi, A. Abdou, M. Al-Rooqi et al. · 0 citations

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