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Open access Oct 2026

Implementing DPYD testing prior to treatment with fluoropyrimidines at Lahey Clinic.

45 Background: Fluoropyrimidines are foundational therapies for the treatment of many cancers. Carriers of pathogenic DPYD variants face a 5–8 fold increased risk of grade ≥3 toxicity. In 2025, the FDA added a boxed warning to the capecitabine label recommending DPYD testing prior to treatment initiation. Despi...

Z. Kayali, B. Labadie, K. D'Silva et al. · 0 citations

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