Author

Zachery R. Gregorich

3 papers indexed here

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Open access Aug 2026

Multimodal Framework of Left Heart–Pulmonary Vascular Remodeling Underlying Right Ventricular Failure in PH-HFpEF

Background: Right ventricular (RV) dysfunction in pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) leads to adverse outcomes, yet the mechanisms underlying RV failure remain incompletely defined. We aimed to develop a multimodal framework integrating vascular mechanics and myocard...

Farhan Raza, Zachery R. Gregorich, Jack Freeman et al. · Circulation: Heart Failure · 0 citations

#protein folding Open access Sep 2026

A Streamlined One-Pot Extraction Method Enables High-Sensitivity Top-Down Proteomic Characterization of Phospholamban from Biopsy-Scale Cardiac Tissue

A streamlined Azo-enabled one-pot extraction strategy for high-sensitivity top-down analysis of PLN that reduces the required tissue input to 1 mg while preserving analytical performance and establishing a practical strategy for TDP of PLN proteoforms from biopsy-scale and other sample-limited myocardial specimens.

Isabella R. Clemmer, Holden T. Rogers, M. C. Wilson et al. · Journal of the American Soci... · 0 citations

Review Open access Sep 2026

Proteoforms in Disease: Biomedical Applications of Top-Down Proteomics

The evolving role of TDP in biomedical research is reviewed, highlighting studies that revealed proteoform-level alterations, identified candidate biomarkers, and advanced the understanding of the roles of proteoforms in human diseases.

Holden T. Rogers, Z. Gregorich, Megan S. Gant et al. · Mass spectrometry reviews (P... · 1 citation