Synthesis, In Silico and In Vitro Evaluation of Cholinesterase and Tyrosinase Inhibition of Benzothiazinones for Cognitive Disorders
Objective: Cognitive disorders, including Alzheimer’s disease (AD) are multifactorial conditions associated with cholinergic dysfunction and oxidative stress linked to abnormal melanogenesis. This study aimed to design, synthesise, and evaluate novel benzothiazinone derivatives for their dual inhibitory activity agains...