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Aug 2026

PDCD4/PPARα axis regulates oxidative stress-mediated microvascular endothelial injury in myocardial ischemia-reperfusion.

Cardiac microvascular endothelial cell (CMEC) injury is a primary driver of microvascular obstruction and the no-reflow phenomenon during myocardial ischemia/reperfusion (I/R). While Programmed Cell Death 4 (PDCD4) is known to exacerbate cardiovascular diseases, its precise role and regulatory mechanisms in CMEC barrie...

Midilibieke Hasidaer, Yu-Chun Yang, Z. Bao et al. · 0 citations
Open access Sep 2026

METTL7B attenuates pathological cardiac hypertrophy via m6A-associated regulation of HK3.

Pathological cardiac hypertrophy is a major contributor to heart failure, yet the epitranscriptomic mechanisms that restrain maladaptive remodeling remain incompletely understood. In this study, we investigated the role of METTL7B and its association with m6A-related regulation of HK3 in pathological cardiac hypertroph...

Z. Bao, Zhi-Qiang Liu, Yu-Chun Yang et al. · 0 citations

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