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Yuxuan Kuang

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Open access Jul 2026

MGST1 Suppresses Ferroptosis in Nucleus Pulposus Cells and Attenuates Intervertebral Disc Degeneration by Regulating GPX4.

MGST1 exhibits compensatory upregulation during the progression of intervertebral disc degeneration and delays its progression by inhibiting ferroptosis in nucleus pulposus cells, a novel mechanism by which MGST1 regulates ferroptosis in IDD and provides a potential molecular target for the prevention and treatment of IDD.

Zhenxin Huo, Ding Li, Yuxuan Kuang et al. · 0 citations

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