Yuto Nakamura

Nuclear RSK1 mediates interferon-γ–induced proinflammatory activation in human primary macrophages and humanized mice

Proinflammatory activation of macrophages promotes various inflammatory disorders. The molecular mechanisms underlying macrophage activation, particularly in the context of nuclear translocation of proinflammatory response mediators, remain obscure. We have used a systems approach to explore key regulators of macrophag...