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Yutei Takahashi

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Open access Aug 2026

Balanced RCC1 activity organizes the specialized spindle midplane during cleavage divisions

Chromosome-bound RCC1 generates Ran-GTP signals to organize functional spindles for faithful chromosome segregation during mitosis and meiosis. RCC1 is the sole guanine nucleotide exchange factor (GEF) for Ran and is essential for spindle assembly during early, but not late, embryonic divisions. However, how RCC1 organ...

Ming Yang, Ai Kiyomitsu, Yutei Takahashi et al. · 0 citations

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