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Yusuke Yoshino

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Open access Oct 2026

Enhanced uric acid degradation attenuates psoriasiform dermatitis via the mtROS–CCL20–CCR6–IL-17 axis

Psoriasis is an interleukin (IL)-23–IL-17–driven chronic inflammatory skin disease characterized by epidermal hyperproliferation. Although psoriasis is frequently associated with hyperuricemia—generally considered a consequence of enhanced local purine metabolism—the direct contribution of uric acid (UA) to psoriatic...

Y. Kimura, S. Takeoka, Yukihiro Yazaki et al. · 0 citations

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