Yusuke Kageyama

Biophysical and structural characterisation of a quasi-stable toxic dimer of amyloid Aβ42 peptide tethered at position 34

Non-fibrillar oligomeric forms of amyloid β (Aβ) mediate toxicity in Alzheimer’s disease (AD) with Aβ accumulation preceding tau aggregation and synaptic damage. Aβ oligomerization is thought to initiate from the smallest stable unit, the dimer, yet structural details of this species remain unclear due to its transient...