Yusef A. Haikal

Proteolytic Activation of T Cell Engagers And Bispecific Proteins Using Modular Coiled-Coil Peptides.

Bispecific T cell engagers (BiTEs) are engineered immunotherapeutic molecules designed to direct the body's immune system against malignant cells by physically connecting T cells to target cells, triggering cytotoxic responses. BiTEs have typically engaged T cells via αCD3 domains, such as OKT3 or UCHT1, which are link...