Harnessing CYP71 Enzymes for Terpenoid Indole Alkaloid Production: A Synthetic Biology Perspective from Discovery to Application
Terpenoid indole alkaloids (TIAs) are a class of structurally diverse natural products with important pharmacological activities. Recently, substantial progress has been made in elucidating TIA biosynthetic pathways, and these studies have revealed the central roles of CYP71 clan enzymes (CYP71s) in both the formatio...