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Review Open access Oct 2026

Biological age acceleration and cardiovascular–kidney–metabolic syndrome progression: evidence from UK Biobank and NHANES

Abstract Objective: We examined associations of biological age acceleration with cardiovascular–kidney–metabolic (CKM) syndrome progression and baseline stage burden. Methods: Longitudinal analyses included 326,218 UK Biobank participants, and cross-sectional analyses included 5,228 NHANES adults. PhenoAge and KDMAge a...

Yu-Kai Zhang, Chen-Wei Zhang, Xin Wang et al. · 0 citations
Review Open access Sep 2026

Immunometabolic Regulation of Macrophage Function in Cardio-Hepatic-Renal Comorbidities: Mechanisms and Therapeutic Opportunities.

This study systematically summarize the roles of macrophage polarization, phenotypic remodeling and metabolic activation in the injury of three metabolic organs, and analyzes their mediating functions in inter-organ immune-metabolic crosstalk and the associated pathological connections.

Xiao-Fan Bai, Jiang Bai, Yun Zhou · 0 citations

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