Open access
Sep 2026
GiGCN: a network-based framework for uncovering synthetic lethal and viable genetic interactions
Abstract Genetic interactions (GIs) underpin the functional connectivity of genes and pathways, and are important for dissecting genotype–phenotype relationships and identifying therapeutic targets for diseases. However, the scale of the human genome restricts systematic experimental interrogation of GIs. Existing comp...
Qi-Zheng Wang, Fan Yang, Meng-Jie Fu et al.
· Briefings in Bioinformatics · 0 citations