Author

Yun-Xin Xu

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Open access Sep 2026

From single-sequence structure prediction to protein fitness landscape through a composable, epistasis-aware mutation atlas

An end-to-end framework named Cerebra-Epistasis is presented, which couples a single-sequence structure predictor that explicitly endows the structure awareness beyond the conventional sequence-fitness mapping with a downstream fitness prediction network that deliberately models the non-linear epistatic effects beyond...

Wei-Zhe Wang, Zi-Mu Yu, En-Di Yang et al. · bioRxiv · 0 citations

Open access Sep 2026

MutCleaner: Cleaning and Standardizing Biological Mutation Datasets for Variant Effect Prediction

Summary Protein mutation datasets are widely used in variant effect prediction and protein engineering, but datasets from different sources often lack consistent conventions for mutation representation, sequence representation, data organization, and experimental labels, making these resources difficult to integrate di...

Zi-Yu Shi, Yu-Xiang Tang, Meng-Xin Yang et al. · bioRxiv · 0 citations