Author

Yun Soo Bae

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Open access Oct 2026

SH3YL1-TLR5 complex-mediated vicious cycle contributes to FSGS pathogenesis

Summary The mechanisms underlying focal segmental glomerulosclerosis (FSGS), particularly podocyte damage, remain unclear. We found that patients with FSGS have significantly elevated serum and urine levels of SH3YL1, especially in more severe cases. Adriamycin stimulates SH3YL1 secretion, which induces proinflammatory...

Hye Eun Lee, J. Ghee, Eun Jung An et al. · iScience · 0 citations

Open access Aug 2026

Molecular Striptease of a Thiadiazolopyrimidine Hit Yields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition

Compound 5, although aqueous solubility issues limited its cellular antiproliferative performance, represents a specific, artifact-free architectural starting point for future selective NOX inhibitor development.

Emanuele Fabbrizi, Andrea Mancini, Chiara Lambona et al. · ACS Medicinal Chemistry Lett... · 0 citations