Preclinical Evaluation of 68Ga-Labeled Heterodimers for Dual Integrin αvβ3 and PARP1-Targeted Tumor Imaging
Tumor heterogeneity limits the diagnostic performance of molecular imaging probes targeting a single biomarker. Here, we report the design, synthesis, and preclinical evaluation of 68Ga-labelled heterodimeric radiotracers co-targeting integrin αvβ3 and poly(ADP-ribose) polymerase 1 (PARP1) through a proposed “binding...