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Open access Oct 2026

SIRT1–Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions

Aging gradually reduces the ability of cells to maintain and restore homeostasis under metabolic and oxidative stress. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that regulates metabolism, mitochondrial function, inflammatory signaling, and cellular stress responses. Its activity depends on NAD+ availability, r...

Meng-Ting Yan, Lin-Rui Hua, Yun-Ju He et al. · 0 citations
Oct 2026

Qi-Fu-Yin Attenuates Frailty by Regulating Gut Microbiota and Neuroendocrine Hormones in 5xFamilial Alzheimer's Disease Transgenic Mice.

Frailty is a common and debilitating feature of Alzheimer's disease (AD), yet effective therapeutic strategies targeting both cognitive decline and physical frailty remain limited. Qi-Fu-Yin (QFY), a traditional Chinese herbal formulation, has been used to treat aging-related disorders, but its effects on frailty in AD...

Xiu Yang, Tian-Yuan Ye, Yun-Ju He et al. · 0 citations

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