Open access
Jul 2026
USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.
De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with ASD, using isogenic human iPSC-derived...
Tae-Hwan Park, I. Koh, Seoyoung Sung et al.
· Molecules and Cells · 0 citations