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Author

Yun-Ji Lim

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2 papers indexed here

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Review Open access Oct 2026

The dynamic landscape of T helper cell plasticity and Th17-Treg instability in periodontitis.

Periodontitis is a chronic inflammatory disease initiated by a dysbiotic microbiome, yet tissue destruction is primarily driven by an exaggerated host immune response. CD4⁺ T helper (Th) cell subsets play important roles in regulating periodontal inflammation and osteoclast-mediated bone resorption through distinct cyt...

Yun-Ji Lim, Tae Sung Kim · 0 citations
Open access Aug 2026

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy

It is shown that anti-CTLA-4 antibody engages CTLA-4 in Tregs specifically in the tumor tissues to reduce their stability and survival and weaken their suppressive function through upregulating TGF-β signaling, which leads to the antibody-mediated - upregulation of CD4+ and CD8+ effector T cell anti-tumor immunity and...

Na Liu, Jun-Ji Xu, Wai Lim Ku et al. · 0 citations

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