Open access
Sep 2026
Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age‐Related Cognitive Inflexibility in Mice
Aging is associated with impairments in cognitive flexibility, a key executive function supported by the medial prefrontal cortex (mPFC), yet the biological mechanisms underlying individual variability in age‐related decline remain poorly understood. Here we investigated behavioral, ultrastructural, and proteomic corre...
Rui Yamada, H. Nagai, C. Numa et al.
· Aging Cell · 0 citations