Aug 2026
Repurposing butoconazole as a GRP78 substrate-binding domain (SBD) inhibitor to induce endoplasmic reticulum stress-mediated apoptosis in triple-negative breast cancer.
Butoconazole is repurposed as a novel allosteric inhibitor of glucose-regulated protein 78 (GRP78) for TNBC treatment and represents a promising lead compound for further development as a systemic anti-TNBC agent through formulation optimization.
Yaowen Song, Ziyue Yuan, Zhi-Jia Li et al.
· Bioorganic chemistry (Print) · 0 citations