Author

Yun Huang

3 papers indexed here

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Open access Oct 2026

Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils Derived from Human Pluripotent Stem Cells

Heart failure remains a leading cause of global morbidity and mortality, with cardiac fibrosis contributing to disease progression. Following myocardial injury, activated cardiac fibroblasts orchestrate adverse extracellular matrix (ECM) remodeling, which leads to tissue stiffening and compromised contractility. Despit...

Gyuhyung Jin, Shao-Hai Fang, Yun Chang et al. · bioRxiv · 0 citations

Open access Sep 2026

PITX2 missense coding variant expression in mice reveals direct function in atrial fibrillation.

Atrial fibrillation (AF) is the most common sustained human cardiac arrhythmia and linked to a drastic increase in stroke and heart failure risk. While sequence variations in the PITX2 non-coding region are the strongest genetic signature of AF risk, the direct role of PITX2 in AF remains a topic of debate. Here, we ge...

Jeffrey D. Steimle, Yue Yuan, Shao-Hai Fang et al. · Journal of Clinical Investig... · 0 citations

Open access Jul 2026

A single-component optogenetic toolkit for reversible visualization and programmable control of microtubule dynamics

A genetically encoded, single-component optogenetic platform for spatiotemporal control of microtubule organization and dynamics is developed, revealing how local microtubule integrity governs lysosomal trafficking and endoplasmic reticulum (ER)-associated signaling dynamics.

Tien-Hung Lan, Guolin Ma, Xiaoxuan Liu et al. · Cell Reports Methods · 0 citations