Author

Yunfeng Zhu

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Open access Sep 2026

Hepatocyte RIPK1 scaffolding function protects against alcohol-induced liver injury by restraining ER stress-driven apoptosis and inflammation

Alcoholic liver disease (ALD) is a global health burden with limited therapeutic options. The pathogenesis of ALD involves hepatocyte death and inflammation, but the key regulatory mechanisms remain incompletely defined. Receptor-interacting protein kinase 1 (RIPK1) is a critical signaling molecule with distinct ki...

Weigao Zhang, Hu Liu, Yun-Feng Zhu et al. · Cell Death & Disease · 0 citations

Open access Aug 2026

Sub‑chronic dietary exposure to environmentally relevant doses of di‑(2‑ethylhexyl) adipate (DEHA) induces hepatic steatosis in female mice via disrupting the PPARγ pathway and inducing endoplasmic reticulum stress: In vivo and in vitro evidence.

It is demonstrated that environmental-level DEHA exposure promoted obesity and hepatic steatosis in female mice by disturbing the PPARγ signaling pathway and upregulating ER stress-related genes, highlighting a significant and previously underappreciated health risk of DEHA in females and calling for a reassessment of...

Si-Yi Lan, Rong Wei, Qingyang Zhang et al. · Ecotoxicology and Environmen... · 0 citations