BACKGROUND
The Sigma-1 receptor (S1R) represents a promising target for faster-onset antidepressants. Nevertheless, the mechanism underlying the delayed onset of therapeutic action exhibited by S1R-activating selective serotonin reuptake inhibitors (SSRIs) remains unclear. Thus, elucidating the role of S1R in mediating...
Peng Ren, Jing-Ya Wang, Jiao-Zhao Yan et al.· Journal of Advanced Research· 0 citations
G protein-coupled receptors (GPCRs) constitute the largest druggable superfamily of membrane proteins and underlie approximately 35% of all approved medicines. Yet this conventional paradigm leaves a substantial minority of neuropsychiatric patients with incomplete efficacy, treatment resistance, or dose-limiting adver...
It is demonstrated that CX3CL1/CX3CR1 signaling-mediated synaptic plasticity played essential roles in ketamine's antidepressant-like effects, which opened a new door to targeting chemokines to improve depression symptoms.
Analysis demonstrated that overexpressing Plxdc2 in mPFC microglia activated the JAK2-STAT1 pathway, enhanced NLG, shifting microglia towards a pro-inflammatory phenotype, worsening deficits in synaptic plasticity and induced depressive-like behaviour, which was reversible by the NLG inhibitor tunicamycin.
Jing-ya Wang, Peng Ren, De-Yi Yang et al.· British Journal of Pharmacol...· 0 citations
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