Synergistic oncogenesis in human cholangiocytes: IDH1 mutation and the biliary microenvironment to drive early transformation and a targetable metabolic dependency in patient-derived organoids.
A novel, physiologically relevant in vitro model that recapitulates the synergistic oncogenesis driven by IDH1 R132C mutation and microenvironmental stress in early CCA is established and provides a preclinical platform for identifying and testing interceptive strategies aimed at reversing or halting early cholangiocar...