Author

Yun Cao

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Open access Sep 2026

Targeting NSUN5-mediated m5C-RNA modification overcomes sunitinib resistance in renal cell carcinoma by suppressing Fibronectin/PI3K/AKT signaling

Sunitinib resistance represents a dominating obstacle for clinical pharmacotherapy of renal cell carcinoma (RCC). Dysregulation of the RNA 5-methylcytosine (m 5 C) modification exerts an important influence on tumor pathogenesis, yet its role and the mechanism underlying RCC sunitinib resistance remain unknown. H...

Chan Huang, M. Luo, Neng-Qiao Wen et al. · Cell Death & Disease · 0 citations

Open access Aug 2026

TFE3‐DualNet: An Interpretable Foundation Model‐Based Deep Learning Ensemble for Diagnosing TFE3‐Rearranged Renal Cell Carcinoma From Whole‐Slide Images in a Two‐Center Cohort

TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is a rare, aggressive subtype that predominantly affects adolescents and young adults. Its marked morphologic heterogeneity can delay recognition and downstream confirmatory testing.

Yu-Hang Chen, Quanhui Xu, Haohua Yao et al. · Cancer Medicine · 0 citations