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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Yun-Cai Chen

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Open access Oct 2026

Peptide signaling in the paraventricular thalamus is essential for disrupted adult reward behaviors consequent to early-life adversity.

Early-life adversity (ELA) is strongly linked to emotional disorders characterized by dysregulated reward behaviors. However, the mechanisms by which transient neonatal experiences generate enduring, sex-specific alterations in brain function remain unresolved. Paraventricular thalamus (PVT) neurons are selectively act...

A. Floriou-Servou, Ryan Weber, Yun-Cai Chen et al. · 0 citations
Open access Oct 2026

SIRT1–Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions

Aging gradually reduces the ability of cells to maintain and restore homeostasis under metabolic and oxidative stress. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that regulates metabolism, mitochondrial function, inflammatory signaling, and cellular stress responses. Its activity depends on NAD+ availability, r...

Meng-Ting Yan, Lin-Rui Hua, Yun-Ju He et al. · 0 citations
Open access Aug 2026

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stress

It is found CRH signaling via CRHR1 indeed disrupts reward behaviors in naïve mice, but is dysregulated in ‘anhedonic’ mice with a history of ELA, and activation of CRH receptor 2 (CRHR2) reverses anhedonia-like behaviors in adult ELA mice.

Matthew T. Birnie, Lara Taniguchi, Lia M. Harvey et al. · 0 citations

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