Regulation of Surfactin Biosynthesis Pathways in Bacillus sp.: Regulatory Network Reconstruction and Metabolic Engineering Perspectives
Surfactin is an amphiphilic lipopeptide, composed of a cyclic heptapeptide linked to a β-hydroxy fatty acid. This structural configuration gives rise to its remarkable biosurfactant properties. The synthesis is performed by a non-ribosomal peptide synthesis mechanism that involves surfactin synthetase, a multi-enzyme c...