Imeglimin provides dual hepatic and skeletal muscle protection in experimental MASH-associated sarcopenia.
BACKGROUND & AIMS Metabolic dysfunction-associated steatohepatitis (MASH) is frequently complicated by sarcopenia, in which mitochondrial dysfunction and inflammatory catabolic signaling are implicated. We investigated whether imeglimin, an antidiabetic mitochondrial modulator, attenuates MASH-associated muscle atrophy...