A forward genetics platform for papillomavirus research
The inability to perform forward genetics has been a major barrier to human papillomavirus (HPV) research. Here, we report a platform for phenotypic selection of HPV mutants. Our method relies on large “concordant” virus libraries, where each mutant virus particle encapsidates the mutant plasmid that encodes it, thereb...
Yuka Takeo, Sydney R. Hirsch, Daniel DiMaio
· Science Advances · 0 citations