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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yuji Itoh

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Open access Aug 2026

Switching Functional DNA-Binding Modes by Tuning Protein Order-Disorder Equilibria

A conserved sequence-ensemble-dynamics code in Nhp6A is revealed wherein not just stability, but also phosphorylation-induced conformational switching, disordered tail dynamics, and DNA binding-bending closely coordinate chromatin accessibility is revealed.

Shilpi Laha, H. Madhan, Yuji Itoh et al. · 0 citations

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