Open access
Aug 2026
Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation
It is demonstrated that CMA activity is downregulated in nucleus pulposus cells from IDD patients and IL‐1β‐induced rat intervertebral disc cell models, causing cytoplasmic accumulation of a novel CMA substrate, Midnolin (MIDN).
Xianglong Chen, Hai-Yang Gao, Wang Wu et al.
· Advancement of science · 0 citations