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Open access Sep 2026

Light- and pH-Gated Reversible Modulation of Peptide Coacervates via Noncovalent Integration of Spiropyran Photoswitches.

Peptide coacervates formed via liquid-liquid phase separation (LLPS) have emerged as versatile cell-like compartments for protocell studies and spatially confined catalysis. However, achieving remote, noninvasive modulation of their assembly‒disassembly lifecycle remains a key challenge. Here, we report a supramolecula...

Yi-Fan Zheng, Ying-Jie Liu, Han-Bo Xu et al. · 0 citations
Oct 2026

Photodynamic Therapy‐Primed and Enzyme Cascade‐Fueled in Situ Prodrug Self‐Assemblies for Self‐Amplifying Chemotherapy

Tumor heterogeneity remains a major translational challenge for targeted therapies, particularly those employing multi‐targeted precision strategies. To overcome this barrier and ensure both high tumor‐specificity and robust clinical efficacy, we designed CBT‐NM‐PPa‐cRGD, a photodynamic therapy (PDT)‐initiated, sel...

Qianzijing Zhang, Yi-Fan Huang, Zian Yu et al. · 0 citations

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