Open access
Sep 2026
IECP: iterative equilibration of cell-type expression profiles improves accuracy of reference-free deconvolution
Abstract Motivation Reference-free deconvolution methods are widely used to estimate cell-type composition and expression profiles from bulk transcriptomic data when native cell type references are unavailable. However, these methods often suffer from systematic biases caused by the asymmetric differential gene express...
Dong-Ping Du, David Herrington, Guo-Qiang Yu et al.
· Bioinformatics · 0 citations