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Open access Oct 2026

An activator-free method for the synthesis of nucleotide 5′–5′ triphosphate mRNA capping agent

The traditional synthesis of nucleotide 5′–5′ triphosphate linkages involves a “2 + 1” phosphate coupling mediated by a large excess of metal salts, where the salt removal is a labor and waste-intensive step. We have omitted the metal salts from this reaction by modulating the solubility and reactivity of the monophosp...

Eric Tam, Viktor Barát, T. Y. Saw et al. · 0 citations
Open access Oct 2026

Programmable design of functional RNAs through multimodal generative learning

RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative model that learns a conditionable design grammar from RNA sequences, experimental structural probing profiles, and functiona...

Jian-Bo Ma, Jiang-Hui Zhu, Wen-Ze Huang et al. · 0 citations

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